Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia.
作者： David J. Braun , Adam D. Bachstetter , Tiffany L. Sudduth , Donna M. Wilcock , D. Martin Watterson
DOI: 10.1007/S11357-019-00072-4
关键词:
摘要: The blood-brain barrier (BBB) is critical in maintenance of brain homeostasis, and loss its functional integrity a key feature across broad range neurological insults. This includes both acute injuries such as traumatic injury stroke, well more chronic pathologies associated with aging, vascular cognitive impairment dementia (VCID). A specific form myosin light chain kinase (MLCK210) major regulator general, including the BBB. Studies have demonstrated potential MLCK210 therapeutic target for peripheral disorders involving tissue dysfunction, but less known about neurologic disorders. We report here that genetic knockout (KO) protects against cerebral microhemorrhages neuroinflammation induced by dietary hyperhomocysteinemia. Overall, results are consistent an accumulating body evidence supporting dysfunction specifically implicate it BBB model VCID.
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