Cysteine S -conjugate β-lyases
作者： A. J. L. Cooper , J. T. Pinto
DOI: 10.1007/S00726-005-0243-4
关键词:
摘要: Cysteine S-conjugate β-lyases are pyridoxal 5′-phosphate-containing enzymes that catalyze β-elimination reactions with cysteine S-conjugates possess an electron-withdrawing group attached at the sulfur. The end products of β-lyase reaction pyruvate, ammonium and a sulfur-containing fragment. If fragment is reactive, parent may be toxic, particularly to kidney mitochondria. Halogenated alkenes examples electrophiles bioactivated (toxified) by conversion S-conjugates. These conjugates converted thioacylating fragments. Several found in allium foods (garlic onion) substrates. This finding account part for chemopreventive activity products. review (1) identifies reactions, (2) suggests toxicant channeling contribute halogenated S-conjugate-induced toxicity mitochondria, (3) proposes mechanisms antiproliferative effects fragments eliminated from allium-derived
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