Anti-proliferate and pro-apoptotic effects of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyranone through inactivation of NF-κB in Human Colon Cancer Cells

作者: Jung Ok Ban , In Guk Hwang , Tae Myoung Kim , Bang Yeon Hwang , Ung Soo Lee

DOI: 10.1007/BF02977371

关键词:

摘要: Many natural compounds have been shown to prevent cancer cell growth through the redox regulation of transcription factors. NF-κB, a factor, has implicated in apoptotic death several cells. This study examined whether or nor 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyranone (DDMP) isolated from onions can modulate activity thereby induce colon Treatment with different DDMP concentrations (0.5–1.5 mg/mL) for various periods (0–48 h) inhibited cells (SW620 and HCT116) followed by induction apoptosis dose dependent manner. It was also found that modulated tumor necrosis factor-α (TNF-α) tetradeanoyl phorbol acetate (TPA)-induced NF-κB transcriptional DNA binding activity. Moreover, suppressed target anti-apoptotic genes (Bcl-2), whereas it induced expression (Bax, cleaved caspase-3 PARP). These results suggest inhibit inducing inhibition NF-κB.

参考文章(29)
Naoko Niho, Michihiro Mutoh, Katsuhisa Sakano, Mami Takahashi, Sachiko Hirano, Haruo Nukaya, Takashi Sugimura, Keiji Wakabayashi, Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea. Cancer Science. ,vol. 97, pp. 248- 251 ,(2006) , 10.1111/J.1349-7006.2006.00167.X
Yumiko Yoshiki, Kazuyoshi Okubo, Active Oxygen Scavenging Activity of DDMP (2,3-Dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one) Saponin in Soybean Seed Bioscience, Biotechnology, and Biochemistry. ,vol. 59, pp. 1556- 1557 ,(1995) , 10.1271/BBB.59.1556
J. Jack Lee, Waun Ki Hong, Bharat B. Aggarwal, Ignacio I. Wistuba, Ximing Tang, Diane Liu, Shishir Shishodia, Natalie Ozburn, Carmen Behrens, Nuclear factor-κB (nf-κB) is frequently expressed in lung cancer and preneoplastic lesions Cancer. ,vol. 107, pp. 2637- 2646 ,(2006) , 10.1002/CNCR.22315
Mark A Berhow, Elizabeth D Wagner, Steven F Vaughn, Michael J Plewa, Characterization and antimutagenic activity of soybean saponins Mutation Research. ,vol. 448, pp. 11- 22 ,(2000) , 10.1016/S0027-5107(99)00225-0
Kensaku TAKARA, Keiko OTSUKA, Koji WADA, Hironori IWASAKI, Masatsugu YAMASHITA, 1,1-Diphenyl-2-picrylhydrazyl Radical Scavenging Activity and Tyrosinase Inhibitory Effects of Constituents of Sugarcane Molasses Bioscience, Biotechnology, and Biochemistry. ,vol. 71, pp. 183- 191 ,(2007) , 10.1271/BBB.60432
Michael Karin, Yixue Cao, Florian R. Greten, Zhi-Wei Li, NF-κB in cancer: from innocent bystander to major culprit Nature Reviews Cancer. ,vol. 2, pp. 301- 310 ,(2002) , 10.1038/NRC780
Seung Ho Lee, Chung Woo Lee, Jae Woong Lee, Myoung Suk Choi, Dong Ju Son, Youn Bok Chung, Chong Kil Lee, Ki Wan Oh, Dong Chul Moon, Byoung Mog Kwon, Jin Tae Hong, Induction of apoptotic cell death by 2′-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-κB in TNF-α-treated SW620 colon cancer cells Biochemical Pharmacology. ,vol. 70, pp. 1147- 1157 ,(2005) , 10.1016/J.BCP.2005.07.028
Matthew R Young, Hsin-Sheng Yang, Nancy H Colburn, Promising molecular targets for cancer prevention: AP-1, NF-κB and Pdcd4 Trends in Molecular Medicine. ,vol. 9, pp. 36- 41 ,(2003) , 10.1016/S1471-4914(02)00009-6
JANET D. PIERCE, JANA PIERCE, STEPHANIE STREMMING, MAHTAB FAKHARI, RICHARD L. CLANCY, The role of apoptosis in respiratory diseases. Clinical Nurse Specialist. ,vol. 21, pp. 22- 28 ,(2007) , 10.1097/00002800-200701000-00006