Role of IL-1β, IL-6 and TNF-α cytokines and TNF-α promoter variability in Plasmodium vivax infection during pregnancy in endemic population of Jharkhand, India.

摘要: Abstract Background The combinatorial effects of Plasmodium infection, perturbation inflammatory responses and the dichotomic role TNF promoter polymorphism has potential clinical physiological relevance during pregnancy. Objective Methods This coordinated orchestration instigated us to investigate circulating level cytokines (IL-1β, TNF-α IL-6) employing ELISA in a stratified group samples plausible genetic association −308 G/A using PCR-RFLP/sequencing vivax infection Results We observed significantly elevated concentrations IL-1β were observed, followed by IL-6 women with malaria (WWM) pregnancy (MIP). Further, IL-1β, detected non-infected group. differential dynamics cytokine concentration each trimester without P. detected. For first time, high was MIP healthy pregnancies. In second trimester, however, we compared sustained third pregnancies acquired level. genotypic distribution for position be nonsignificant mildly associated (OR = 1.4) WWM (OR = 1.2). Moreover, based on distribution, well-correlated mutant homozygote genotype (AA; p = 0.001) heterozygotes (GA; p = 0.0001) ancestral genotypes (GG; both subjects. Conclusion observation may regarded as prognostic marker Most particularly, its polymorphic variability region indicate susceptibility influence risk malaria.