Association of −308G/A TNF-α gene polymorphism and spontaneous preterm birth in Acehnese ethnic group, Indonesia: This polymorphism is not associated with preterm birth

摘要: Background : Single nucleotide polymorphism (SNP) within tumor necrosis factor alpha (TNF-α) gene promoter (308G/A TNFA ) is associated with higher expression. The role of this SNP as a risk for spontaneous preterm birth has been assessed in some regions and the findings were significantly different between race and ethnic groups. Aim To provide the scientific evidence whether allele A 308G/A promoter is among Acehnese or not. Subjects methods In this case–control study, genotypes of among 40 patients 40 term determined by realtime polymerase chain reaction (RT-PCR). concentrations TNF-α from blood measured by enzyme-linked immunosorbent assay (ELISA). differences genotype distributions, dominant recessive models, frequencies case control groups analyzed with Chi-squared test. Deviation Hardy–Weinberg equilibrium (HWE) was Fisher’s exact