Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-α 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants.
作者： Abolfazl Khoshdel , Soleiman Kheiri , Peyman Omidvari , Fahimeh Moradi , Majid Hamidi
DOI: 10.1155/2017/6386453
关键词: Pediatrics 、 Polymorphism (computer science) 、 Restriction fragment length polymorphism 、 Interleukin 、 Case-control study 、 Internal medicine 、 Incidence (epidemiology) 、 Gestational age 、 Gastroenterology 、 Genotype 、 Respiratory distress 、 Medicine
摘要: Cytokine polymorphisms may contribute to the prevalence of respiratory distress syndrome. The present study was done investigate frequency interleukin- (IL-) 10 and tumor necrosis factor- (TNF-) α gene their association with risk RDS in preterm infants. One-hundred nineteen patients 119 healthy infants were enrolled. PCR restriction fragment length polymorphism used determine IL-10 TNF-α genotypes at -1082 A -308 A, respectively. out 238 had (50%). age mothers gestational ranged 17-45 (mean: 28.6 ± 5.3) years 24-34 34.3 2.38) weeks, Totally, 23 deaths recorded group. Incidence TNF-α-308 A/A G/A 84% 16%, TNF-a-308 G/G not found both groups. Prevalence IL-10-1082 variants 65.5% 34.5%, incidence allele G lower group (P < 0.05). We that correlated sex, age, IL-10-1082.
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