Complement alternative pathway genetic variation and Dengue infection in the Thai population.

摘要: Dengue disease is a mosquito-borne infection caused by virus. Infection may be asymptomatic or variably manifest as mild fever (DF) to the most severe form, haemorrhagic (DHF). Mechanisms that influence severity are not understood. Complement, an integral component of immune system, activated during and degree activation increases with severity. Activation complement alternative pathway influenced polymorphisms within (factor B rs12614/rs641153, C3 rs2230199) regulatory [complement factor H (CFH) rs800292] proteins, collectively termed complotype. Here, we tested hypothesis complotype influences secondary infection. In addition complotype, also assessed two other disease-associated CFH (rs1061170, rs3753394) structural polymorphism protein family. We did detect any significant association between examined in Thai population. However, minor allele frequencies were less than 10%, so our study was sufficiently powered at these loci. unable direct interaction NS1 using both recombinant DV2-infected culture supernatants. conclude does