Tail suspension increases energy expenditure independently of the melanocortin system in mice.

作者: Pei San Lew , Davie Wong , Takafumi Yamaguchi , Arnold Leckstrom , Jacquie Schwartz

DOI: 10.1139/Y09-074

关键词:

摘要: Space travelers experience anorexia and body weight loss in a microgravity environment, microgravity-like situations cause changes hypothalamic activity. Hypothalamic melanocortins play critical role the regulation of metabolism. Therefore, we hypothesized that affects metabolism through alterations specific signaling pathways, including melanocortin signaling. To address this hypothesis, situation was produced by an antiorthostatic tail suspension wild-type agouti mice, effect on energy expenditure gene expression examined. Energy measured using indirect calorimetry before during protocol. tissues were collected for analysis at end 3 h period. Tail significantly increased oxygen consumption, carbon dioxide production, heat production mice. suspension-induced inc...

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