Hemolytic drugs aniline and dapsone induce iron release in erythrocytes and increase the free iron pool in spleen and liver

摘要: Abstract Incubation of rat erythrocytes with the hydroxylated metabolites aniline and dapsone (4-4′-diaminodiphenylsulfone), phenylhydroxylamine hydroxylamine, respectively, induced marked release iron methemoglobin formation. On contrary, no nor formation was seen when were incubated parent compounds (aniline dapsone). The acute intoxication rats or a increase in erythrocyte content free methemoglobin, indicating that xenobiotics are effective only after biotransformation to toxic vivo. Prolonged administration produced continuos from erythrocytes. Marked overload spleen liver Kupffer cells, as detected histochemically. weight these subchronically treated animals significantly increased. pool markedly increased lower extent liver. possible relationships between erythrocytes, oxidative damage senescent hemolysis, overwhelmed capacity keep storage forms subsequent low molecular weight, catalitically active is discussed.