A posterior-to-anterior shift of brain functional dynamics in aging.
作者： Han Zhang , Annie Lee , Anqi Qiu
DOI: 10.1007/S00429-017-1425-Z
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摘要: Convergent evidence from task-based functional magnetic resonance imaging (fMRI) studies suggests a posterior-to-anterior shift as an adaptive compensatory scaffolding mechanism for aging. This study aimed to investigate whether brain dynamics at rest follow the same aging using large Chinese sample aged 22 79 years (n = 277). We defined probability of regions being hubs over period time characterize hub dynamic, and variability connectivity dynamic resting-state fMRI. Our results revealed that both posited age-related shift. Specifically, posterior region showed attenuated dynamics, while anterior augmented in Interestingly, our analysis further indicated episodic memory decline was associated with decrease regions. Hence, these findings provided new dimension view based on dynamics.
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