New insights into the in vivo function of heterotrimeric G-proteins through gene deletion studies
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摘要: A huge number of receptors signals through heterotrimeric G-proteins to regulate a wide variety of physiological processes. The ability to modify G-protein expression in vivo provides a …
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D.T. Hung, Y.H. Wong, T.K. Vu, S.R. Coughlin, The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase. Journal of Biological Chemistry. ,vol. 267, pp. 20831- 20834 ,(1992) , 10.1016/S0021-9258(19)36762-6
D Wu, A Katz, C.H. Lee, M.I. Simon, Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family. Journal of Biological Chemistry. ,vol. 267, pp. 25798- 25802 ,(1992) , 10.1016/S0021-9258(18)35680-1
R.L. Wange, A.V. Smrcka, P.C. Sternweis, J.H. Exton, Photoaffinity labeling of two rat liver plasma membrane proteins with [32P]gamma-azidoanilido GTP in response to vasopressin. Immunologic identification as alpha subunits of the Gq class of G proteins Journal of Biological Chemistry. ,vol. 266, pp. 11409- 11412 ,(1991) , 10.1016/S0021-9258(18)98970-2
J.R. Raymond, J.M. Arthur, S.J. Casañas, C.L. Olsen, T.W. Gettys, R.M. Mortensen, Alpha 2A adrenergic receptors inhibit cAMP accumulation in embryonic stem cells which lack Gi alpha 2. Journal of Biological Chemistry. ,vol. 269, pp. 13073- 13075 ,(1994) , 10.1016/S0021-9258(17)36798-4
Stuart Yarfitz, James B. Hurley, Transduction mechanisms of vertebrate and invertebrate photoreceptors. Journal of Biological Chemistry. ,vol. 269, pp. 14329- 14332 ,(1994) , 10.1016/S0021-9258(17)36620-6
L Birnbaumer, L Birnbaumer, C E Hörnquist, U Rudolph, U Rudolph, G R Harriman, X Lu, P M Rogers-Fani, S Shappell, G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. Journal of Immunology. ,vol. 158, pp. 1068- 1077 ,(1997)
Marco Baggiolini, Chemokines and leukocyte traffic Nature. ,vol. 392, pp. 565- 568 ,(1998) , 10.1038/33340
Christopher M. Moxham, Craig C. Malbon, Insulin action impaired by deficiency of the G-protein subunit G iα2 Nature. ,vol. 379, pp. 840- 844 ,(1996) , 10.1038/379840A0
A. Shenker, P. Goldsmith, C.G. Unson, A.M. Spiegel, The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family. Journal of Biological Chemistry. ,vol. 266, pp. 9309- 9313 ,(1991) , 10.1016/S0021-9258(18)31586-2
Stefan Offermanns, Christopher F. Toombs, Yi-Hui Hu, Melvin I. Simon, Defective platelet activation in G alpha q deficient mice Nature. ,vol. 389, pp. 183- 186 ,(1997) , 10.1038/38284