Patterns of Positive Specimen Margins and Detectable Prostate Specific Antigen After Radical Perineal Prostatectomy

摘要: AbstractPositive specimen margins and detectable postoperative prostate specific antigen (PSA) levels were analyzed after 200 consecutive radical perineal prostatectomies for clinical stages T1 T2 adenocarcinoma of the prostate. Clinical parameters that correlated with lymph node metastases in concomitant pelvic lymphadenectomies also noted. At a mean followup 35 months 79 percent patients had undetectable PSA levels. Step-section pathological analysis specimens obtained by either nerve sparing or extended modifications revealed 41 tumors organ confined 56 negative margins. Selective sacrifice posterolateral periprostatic fascia enclosed neurovascular bundle achieved despite capsular penetration 15 all patients. Of positive approach, solitary apical infrequent (7 16 percent, respec...