1H NMR investigation of solvent effects in aromatic stacking interactions

摘要: One of the marquis challenges in modern Organic Chemistry concerns design and synthesis abiotic compounds that emulate exquisite complex structures and/or functions biological macromolecules. Oligomers possessing propensity to adopt well-defined compact conformations, or foldamers, have been attained utilizing hydrogen bonding, torsional restriction, solvophobic interactions.1 In this laboratory, aromatic electron donor−acceptor interactions exploited aedamersfoldamers a novel, pleated secondary structure aqueous solution. Herein is reported detailed 1H NMR binding studies aedamer monomers were carried out solvents solvent mixtures covering broad polarity range. Curve-fitting analysis data using model incorporated formation higher order self-associated complexes yielded linear free energy relationship between complexation empirical parameter, ET(30)...