Fungal allergy in asthma–state of the art and research needs

摘要: Sensitization to fungi and long term or uncontrolled fungal infection are associated with poor control of asthma, the likelihood more severe disease complications such as bronchiectasis chronic pulmonary aspergillosis. Modelling suggests that >6.5 million people have asthma sensitizations (SAFS), up 50% adult asthmatics attending secondary care sensitization, an estimated 4.8 adults allergic bronchopulmonary aspergillosis (ABPA). There is much uncertainty about which allergens relevant natural history sensitisation fungi, if there exposure response relationship for allergy, pathogenesis frequency exacerbations complications. Genetic associations been described but only weakly linked phenotypes. The evidence base most management strategies in ABPA, SAFS related conditions weak. Yet straightforward clinical practice guidelines required. role environmental monitoring optimal means controlling prevent disability not yet clear. In this paper we set out key supporting exposure, asthmatics, what understood identify numerous areas research studies.