Retinoic Acid Induces Ubiquitination-Resistant RIP140/LSD1 Complex to Fine-TunePax6Gene in Neuronal Differentiation
作者： Cheng-Ying Wu , Shawna D. Persaud , Li-Na Wei
DOI: 10.1002/STEM.2190
关键词:
摘要: Receptor-interacting protein 140 (RIP140) is a wide-spectrum coregulator for hormonal regulation of gene expression, but its activity in development/stem cell differentiation unknown. Here, we identify RIP140 as an immediate retinoic acid (RA)-induced dual-function chaperone LSD1 (lysine-specific demethylase 1). protects LSD1's catalytic domain and antagonizes Jade-2-mediated ubiquitination degradation. In RA-induced neuronal differentiation, the increased RIP140/LSD1 complex recruited by RA-elevated Pit-1 to specifically reduce H3K4me2 modification on Pax6 promoter, thereby repressing RA-induction Pax6. This study reveals new repressive mechanism that modulates abundance, enzyme quality, recruitment histone modifier regulator Pax6, which provides homeostatic control RA induction differentiation.
elsevier.com
sci-hub.se 参考文章(39)
Li-Na Wei, Xinli Hu, Dhyan Chandra, Edward Seto, Maria Farooqui, Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing. Journal of Biological Chemistry. ,vol. 275, pp. 40782- 40787 ,(2000) , 10.1074/JBC.M004821200
Xinli Hu, Yixin Chen, Mariya Farooqui, Mary C. Thomas, Cheng-Ming Chiang, Li-Na Wei, Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity,and gene activation Journal of Biological Chemistry. ,vol. 279, pp. 319- 325 ,(2004) , 10.1074/JBC.M307621200
Nurit Ballas, Christopher Grunseich, Diane D. Lu, Joan C. Speh, Gail Mandel, REST and Its Corepressors Mediate Plasticity of Neuronal Gene Chromatin throughout Neurogenesis Cell. ,vol. 121, pp. 645- 657 ,(2005) , 10.1016/J.CELL.2005.03.013
Thomas J. Cunningham, Gregg Duester, Mechanisms of retinoic acid signalling and its roles in organ and limb development Nature Reviews Molecular Cell Biology. ,vol. 16, pp. 110- 123 ,(2015) , 10.1038/NRM3932
Tony Oosterveen, Sanja Kurdija, Zhanna Alekseenko, Christopher W. Uhde, Maria Bergsland, Magnus Sandberg, Elisabet Andersson, José M. Dias, Jonas Muhr, Johan Ericson, Mechanistic Differences in the Transcriptional Interpretation of Local and Long-Range Shh Morphogen Signaling Developmental Cell. ,vol. 23, pp. 1006- 1019 ,(2012) , 10.1016/J.DEVCEL.2012.09.015
Ping-Chih Ho, Yao-Chen Tsui, Xudong Feng, David R Greaves, Li-Na Wei, NF-κB-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance Nature Immunology. ,vol. 13, pp. 379- 386 ,(2012) , 10.1038/NI.2238
Sophie Bel-Vialar, François Medevielle, Fabienne Pituello, The on/off of Pax6 controls the tempo of neuronal differentiation in the developing spinal cord. Developmental Biology. ,vol. 305, pp. 659- 673 ,(2007) , 10.1016/J.YDBIO.2007.02.012
F. Duclot, M. Lapierre, S. Fritsch, R. White, M. G. Parker, T. Maurice, V. Cavaillès, Cognitive impairments in adult mice with constitutive inactivation of RIP140 gene expression. Genes, Brain and Behavior. ,vol. 11, pp. 69- 78 ,(2012) , 10.1111/J.1601-183X.2011.00731.X
Stephen N. Sansom, Dean S. Griffiths, Andrea Faedo, Dirk-Jan Kleinjan, Youlin Ruan, James Smith, Veronica van Heyningen, John L. Rubenstein, Frederick J. Livesey, The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis PLoS Genetics. ,vol. 5, pp. e1000511- ,(2009) , 10.1371/JOURNAL.PGEN.1000511
S. Flaisher-Grinberg, H.C. Tsai, X. Feng, L.N. Wei, Emotional regulatory function of Receptor Interacting Protein 140 revealed in the ventromedial hypothalamus Brain Behavior and Immunity. ,vol. 40, pp. 226- 234 ,(2014) , 10.1016/J.BBI.2014.03.019