FORMULATION, OPTIMIZATION AND EVALUATION OF ENROFLOXACIN SOLID LIPID NANOPARTICLES FOR SUSTAINED ORAL DELIVERY
作者： P. . Senthilkumar , P. , Arivuchelvan , A. , Jagadeeswaran
DOI:
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摘要: The objective of the present study was to formulate and evaluate enrofloxacin SLNs using a hot homogenization coupled with ultrasonication method. were prepared tripalmitin as lipid carrier, tween 80 span surfactants poly vinyl alcohol (PVA) stabilizer. influence factors such concentration composition surfactant on particle size investigated optimize formulations. optimized formulations utilized entrap 0.1% characterized for size, polydispersity index, zeta potential (using dynamic light scattering), shape atomic force microscopy transmission electron microscopy), drug encapsulation efficiency by dialysis ultracentrifugation methods), in vitro release dialysis). analyzed FT-IR spectroscopy confirm cross-linking reaction between drug, surfactants. results demonstrated that polydispersivity potential, loading capacity 154.72± 6.11nm, 0.42±0.11, -28.83±0.60mV, 59.66±3.22% 6.13±0.32%, respectively. TEM AFM images showed spherical circular particles well defined periphery. In exhibited biphasic pattern an initial burst 18% within 2h followed sustained over 96h. suggested during process formulations, have not reacted give rise reactant products it only physical mixture.
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