Formulation and Characterization of Itraconazole as Nanosuspension Dosage Form for Enhancement of Solubility

摘要: Abstract             Itraconazole is a triazole antifungal given orally for the treatment of oropharyngeal and vulvovaginal candidiasis, systemic infections including aspergillosis, candidiasis,  prophylaxis fungal in immunocompromised patients.            The study aimed to formulate practical water-insoluble Itraconazole, with insufficient bioavailability as nanosuspension increase aqueous solubility improve its dissolution oral bioavailability.           was produced by solvent-antisolvent nanoprecipitation method presence different stabilisers (Poloxamer-188, HPMCE5) at ratios drug alone or combination surfactant(tween 80, SLS).          The results exhibit that particle sizes all prepared itraconazole formulations were nano size.  best formula (F6) has ( 42  ) nm Zeta potential (- 21.86 mV.  In vitro cumulative release from (88 %) (30) min when compared pure (13%) lyophilized nanoparticles (98.2%) (30)min. Effect parameters investigated.           Fourier transforms infrared spectroscopy(FTIR), Differential scanning calorimetry (DSC) X-ray diffraction (XRD), Scanning electron microscope( SEM) done optimized  lyophilization technique         Thus, Nanosuspension appears be an encouraging approach high rate.               Keywords: Nanoprecipitation method,