Cardiac Disorders i n Children with B - Thalassemia Major

摘要: C ardiac failure due to transfusional iron overload is the maj or cause of death in patients with β - thalassemia major. Also ineffective erythropoiesis and increased gastrointestinal absorption lead body this induced heart failure. For reason, regular evaluation cardiac function recommended for all as integral part their management identify early changes left ventricular function.The study was conducted Qom Children’s Hospital, Iran, from 1st March 2008 30 th October 2012; 140 confirmed cases o f major andcontrol group consisted 50 healthy children. were diagnosed on basis hemoglobin electrophoresis. 2 D, M mode Doppler echocardiography performed cases. Statistical comparis controls by using unpaired t test. The age ranged 3 year 22years mean 14.25 years. There 86 (61%) males 54 (39%) females. All irregular chelation therapy 42 (33%) had LV dysfunction; global dysfunction. Left dimensions, stroke volume E/A ratio considerably affected group. A significant percentage have This ma inly chronic anemia, .Regular monitoring may reduce complication a great extent.