Immune effector mechanisms in malaria.

摘要: SUMMARY That humans in endemic areas become immune to malaria offers encouragement the idea of developing protective vaccines. However natural immunity is relatively inefficient, being bought at cost substantial childhood mortality, and current vaccines are only partially protective. Understanding potential targets mechanisms important development evaluation future Some problems identifying such naturally exposed may stem from conceptual methodological issues related defining who a population susceptible, responsiveness single time points antigenic polymorphism, as well failure many approaches examine functional aspects response. Protective responses be directed pre erythrocytic parasite, free merozoite blood stage parasite or new antigens induced on infected red cell surface. Tackling protection response, together with studies that combine assays allelic exchange gene knock out offer opportunities for better key mechanisms.