Early diagnosis of subependymal giant cell astrocytoma in children with tuberous sclerosis

摘要: Objectives—Intraventricular astrocytomas (subependymal giant cell astrocytomas) of tuberous sclerosis have a poor prognosis due to the obstruction CSF flow. The aim this study was determine whether they could be diVerentiated during childhood and at an early preclinical stage, from subependymal nodules without any growing potential. Methods—The first two MRIs all children referred neuropaediatric centre between 1987 1996 were retrospectively blindly reviewed. Results—Out 60 patients, 24 disclosed localised near foramen Monro, eight developed astrocytomas. Subependymal detectable on MRI 1 year age in cases evidence growth occurred 9 years (mean 4 years). At had diVerent characteristics patients who those did not. over 5 mm diameter that incompletely calcified enhanced by gadolinium higher risk growing, particularly with familial history sclerosis. To detect earlier sclerosis, it is advisible systematically perform examination before 2 repeat every if patient has factors for developing (J Neurol Neurosurg Psychiatry 1999;66:370‐375)