An overview of sleep and circadian dysfunction in Parkinson's disease

摘要: Sleep and circadian alterations are amongst the very first symptoms experienced in Parkinson's disease, sleep present majority of patients with overt clinical manifestation disease. However, magnitude dysfunction its influence on pathophysiology disease remains often unclear a matter debate. In particular, confounding influences dopaminergic therapy major challenge, need to be more carefully addressed studies. The scope this narrative review is summarise current knowledge around both We provide an overview frequency excessive daytime sleepiness, insomnia, restless legs, obstructive apnea nocturia as well addressing structure, rapid eye movement behaviour disorder features disorders have been linked pathological conditions that co-morbid including cognitive decline, memory impairment neurodegeneration. Therefore, targeting could one earliest most promising opportunities slow progression. hope will contribute advance discussion inform new research efforts progress our field.