Cross-Linked Small-Molecule Micelle-Based Drug Delivery System: Concept, Synthesis, and Biological Evaluation
作者： Chunyan Liao , Yun Chen , Yongchao Yao , Shiyong Zhang , Zhongwei Gu
DOI: 10.1021/ACS.CHEMMATER.6B02965
关键词:
摘要: Lessons from the covalent capture of small-molecule self-assemblies (monomer molecular weight <500.0) are applied to grow a generic cross-linked micelle-based drug delivery system (CSM-DDS), which has significant advantages over popular polymeric systems in terms loading, stability, monomer purity, and cost preparation. A proof-of-concept CSM-DDS constructed by one-step synthesized amphiphile 1 with anticancer gemcitabine confirms feasibility new strategy via its high loading content (up 58%), robust superior predictable biosafety, facile functionalization, remarkable activity both vitro vivo.
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