The combined determination of proliferative activity and cell density in the prognosis of adult patients with supratentorial high-grade astrocytic tumors.

摘要: Tumor growth represents the ratio between cell gain (number of mitoses per unit time, i.e., proliferative activity) and loss deaths during same time). While in adults, activity parallels level malignancy astrocytic tumors therefore a useful diagnostic marker, has never been concomitantly assessed this type. We hypothesize that density assessable on histologic slides loss. This hypothesis concerns only diffuse type tumors. Proliferative (assessed by MIB1 antigen immunostain) were thus quantitatively means image processor series 54 supratentorial adult patients, which included 15 astrocytomas (ASTs), 18 anaplastic (ANAs), 21 glioblastomas (GBMs). The results show highly correlated (P = .003) both with histopathologic grade. patients high-grade tumor (i.e., ANA or GBM) exhibited low but high survived for significantly shorter periods than did .002). less time < .05). A marked difference survival was observed .001). concomitant determination seems likely to enable few who have will survive considerable period (several years).