Dynamic contrast enhanced MRI parameters and tumor cellularity in a rat model of cerebral glioma at 7 T.

摘要: Purpose To test the hypothesis that a noninvasive dynamic contrast enhanced MRI (DCE-MRI) derived interstitial volume fraction (ve) and/or distribution (VD) were correlated with tumor cellularity in cerebral tumor. Methods T1-weighted DCE-MRI studies performed 18 athymic rats implanted U251 xenografts. After DCE-MRI, sectioned brain tissues stained Hematoxylin and Eosin for cell counting. Using Standard Model analysis Logan graphical plot, image sets during after injection of gadolinium agent used to estimate parameters plasma (vp), forward transfer constant (Ktrans), ve, VD. Results Parameter values regions where standard model was selected as best were: (mean ± S.D.): vp = (0.81 0.40)%, Ktrans (2.09 0.65) × 10−2 min−1, ve (6.65 1.86)%, VD (7.21 1.98)%. The Logan-estimated strongly model's + (r 0.91, P < 0.001). parameters, VD, significantly ≥ −0.75, 0.001 both). Conclusion These data suggest can be estimated noninvasively by thus supporting its utility assessing pathophysiology. Magn Reson Med 71:2206–2214, 2014. © 2013 Wiley Periodicals, Inc.