Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: rat cerebral glioma blood volume determination.
作者： Xin Li , William D. Rooney , Csanád G. Várallyay , Seymur Gahramanov , Leslie L. Muldoon
DOI: 10.1016/J.JMR.2010.07.004
关键词: Shutter speed 、 Volume fraction 、 Extravasation 、 Biomedical engineering 、 Dynamic contrast-enhanced MRI 、 Blood volume 、 Patlak plot 、 Glioma 、 Chemistry 、 Magnetic resonance imaging
摘要: Abstract The accurate mapping of the tumor blood volume (TBV) fraction (vb) is a highly desired imaging biometric goal. It commonly thought that achieving this difficult, if not impossible, when small molecule contrast reagents (CRs) are used for T1-weighted (Dynamic-Contrast-Enhanced) DCE-MRI technique. This because angiogenic malignant vessels allow facile CR extravasation. Here, three-site equilibrium water exchange model applied to data from cerebrally-implanted rat brain U87 glioma, exhibiting rapid Analyses segments (and entire) DCE time-course with “shutter-speed” pharmacokinetic model, which admits finite kinetics, TBV estimation first-pass segment. Pairwise parameter determinances were tested grid searches 2D parametric error surfaces. Tumor (vb), as well ve (the extracellular, extravascular space fraction), and Ktrans (a extravasation rate measure) maps presented. role Patlak Plot in also considered.
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H. B. W. Larsson, M. Stubgaard, J. L. Frederiksen, M. Jensen, O. Henriksen, O. B. Paulson, Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors Magnetic Resonance in Medicine. ,vol. 16, pp. 117- 131 ,(1990) , 10.1002/MRM.1910160111
Edward Preston, David O. Foster, Diffusion into rat brain of contrast and shift reagents for magnetic resonance imaging and spectroscopy NMR in Biomedicine. ,vol. 6, pp. 339- 344 ,(1993) , 10.1002/NBM.1940060510
Y.R. Kim, K.J. Rebro, K.M. Schmainda, Water exchange and inflow affect the accuracy of T1-GRE blood volume measurements: implications for the evaluation of tumor angiogenesis Magnetic Resonance in Medicine. ,vol. 47, pp. 1110- 1120 ,(2002) , 10.1002/MRM.10175
Ronald G. Blasberg, Joseph D. Fenstermacher, Clifford S. Patlak, Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes Journal of Cerebral Blood Flow and Metabolism. ,vol. 3, pp. 8- 32 ,(1983) , 10.1038/JCBFM.1983.2
Rakesh K. Jain, Emmanuelle di Tomaso, Dan G. Duda, Jay S. Loeffler, A. Gregory Sorensen, Tracy T. Batchelor, Angiogenesis in brain tumours Nature Reviews Neuroscience. ,vol. 8, pp. 610- 622 ,(2007) , 10.1038/NRN2175
C P Rose, C A Goresky, G G Bach, The capillary and sarcolemmal barriers in the heart. An exploration of labeled water permeability. Circulation Research. ,vol. 41, pp. 515- 533 ,(1977) , 10.1161/01.RES.41.4.515
Christian Schwarzbauer, Sean P. Morrissey, Ralf Deichmann, Claudia Hillenbrand, Jutta Syha, Holger Adolf, Ulrike Nöth, Axel Haase, Quantitative magnetic resonance imaging of capillary water permeability and regional blood volume with an intravascular MR contrast agent Magnetic Resonance in Medicine. ,vol. 37, pp. 769- 777 ,(1997) , 10.1002/MRM.1910370521
Thomas E. Yankeelov, William D. Rooney, Wei Huang, Jonathan P. Dyke, Xin Li, Alina Tudorica, Jing-Huei Lee, Jason A. Koutcher, Charles S. Springer, Evidence for shutter-speed variation in CR bolus-tracking studies of human pathology NMR in Biomedicine. ,vol. 18, pp. 173- 185 ,(2005) , 10.1002/NBM.938
Xin Li, Wei Huang, Thomas E. Yankeelov, Alina Tudorica, William D. Rooney, Charles S. Springer, Shutter-speed analysis of contrast reagent bolus-tracking data: Preliminary observations in benign and malignant breast disease. Magnetic Resonance in Medicine. ,vol. 53, pp. 724- 729 ,(2005) , 10.1002/MRM.20405
M. Schwab, R. Bauer, U. Zwiener, The distribution of normal brain water content in Wistar rats and its increase due to ischemia Brain Research. ,vol. 749, pp. 82- 87 ,(1997) , 10.1016/S0006-8993(96)01165-1