Intratumor distribution and test–retest comparisons of physiological parameters quantified by dynamic contrast‐enhanced MRI in rat U251 glioma
作者： Madhava P. Aryal , Tavarekere N. Nagaraja , Stephen L. Brown , Mei Lu , Hassan Bagher-Ebadian
DOI: 10.1002/NBM.3178
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摘要: The distribution of dynamic contrast-enhanced MRI (DCE-MRI) parametric estimates in a rat U251 glioma model was analyzed. Using Magnevist as contrast agent (CA), 17 nude rats implanted with cerebral were studied by DCE-MRI twice 24 h interval. A data-driven analysis selected one three models to estimate either (1) plasma volume (vp), (2) vp and forward transfer constant (Ktrans) or (3) vp, Ktrans interstitial fraction (ve), constituting Models 1, 2 3, respectively. CA (VD) estimated Model 3 regions Logan plots. Regions interest (ROIs) model. In the ROI, descriptors parameter distributions – mean, median, variance skewness calculated compared between two time points for repeatability. All ROIs positively skewed. Test–retest differences population summaries any not significant (p ≥ 0.10; Wilcoxon signed-rank paired t tests). These similar measures test–retest from other tumor can be used inform choice biomarkers that best summarize status treatment effects. Copyright © 2014 John Wiley & Sons, Ltd.
sci-hub.se 参考文章(29)
Madhava P. Aryal, Tavarekere N. Nagaraja, Kelly A. Keenan, Hassan Bagher-Ebadian, Swayamprava Panda, Stephen L. Brown, Glauber Cabral, Joseph D. Fenstermacher, James R. Ewing, Dynamic contrast enhanced MRI parameters and tumor cellularity in a rat model of cerebral glioma at 7 T. Magnetic Resonance in Medicine. ,vol. 71, pp. 2206- 2214 ,(2014) , 10.1002/MRM.24873
James R. Ewing, Hassan Bagher-Ebadian, Model Selection in Measures of Vascular Parameters using Dynamic Contrast Enhanced MRI: Experimental and Clinical Applications NMR in Biomedicine. ,vol. 26, pp. 1028- 1041 ,(2013) , 10.1002/NBM.2996
T. Tihan, W.P. Dillon, S. Cha, A. Lai, M.-H. Chen, L. Yang, M. Wendland, G. Johnson, Comparison of microvascular permeability measurements, K(trans), determined with conventional steady-state T1-weighted and first-pass T2*-weighted MR imaging methods in gliomas and meningiomas. American Journal of Neuroradiology. ,vol. 27, pp. 409- 417 ,(2006)
T Sugahara, Y Korogi, M Kochi, I Ikushima, T Hirai, T Okuda, Y Shigematsu, L Liang, Y Ge, Y Ushio, M Takahashi, Correlation of MR imaging-determined cerebral blood volume maps with histologic and angiographic determination of vascularity of gliomas. American Journal of Roentgenology. ,vol. 171, pp. 1479- 1486 ,(1998) , 10.2214/AJR.171.6.9843274
Ruediger E. Port, Lisa J. Bernstein, Daniel P. Barboriak, Lu Xu, Timothy P. L. Roberts, Nicholas van Bruggen, Noncompartmental kinetic analysis of DCE‐MRI data from malignant tumors: Application to glioblastoma treated with bevacizumab Magnetic Resonance in Medicine. ,vol. 64, pp. 408- 417 ,(2010) , 10.1002/MRM.22399
James R. Ewing, Robert A. Knight, Tavarekere N. Nagaraja, John S. Yee, Vijaya Nagesh, Polly A. Whitton, Lian Li, Joseph D. Fenstermacher, Patlak plots of Gd-DTPA MRI data yield blood–brain transfer constants concordant with those of 14C-sucrose in areas of blood–brain opening Magnetic Resonance in Medicine. ,vol. 50, pp. 283- 292 ,(2003) , 10.1002/MRM.10524
Anwar R. Padhani, Carmel Hayes, Sabine Landau, Martin O. Leach, Reproducibility of quantitative dynamic MRI of normal human tissues NMR in Biomedicine. ,vol. 15, pp. 143- 153 ,(2002) , 10.1002/NBM.732
Michael Ingrisch, Steven Sourbron, Dominik Morhard, Birgit Ertl-Wagner, Tania Kümpfel, Reinhard Hohlfeld, Maximilian Reiser, Christian Glaser, Quantification of perfusion and permeability in multiple sclerosis: dynamic contrast-enhanced MRI in 3D at 3T. Investigative Radiology. ,vol. 47, pp. 252- 258 ,(2012) , 10.1097/RLI.0B013E31823BFC97
Tavarekere N. Nagaraja, Kishor Karki, James R. Ewing, George W. Divine, Joseph D. Fenstermacher, Clifford S. Patlak, Robert A. Knight, The MRI-measured arterial input function resulting from a bolus injection of Gd-DTPA in a rat model of stroke slightly underestimates that of Gd-[14C]DTPA and marginally overestimates the blood-to-brain influx rate constant determined by Patlak plots Magnetic Resonance in Medicine. ,vol. 63, pp. 1502- 1509 ,(2010) , 10.1002/MRM.22339
Xin Li, William D. Rooney, Csanád G. Várallyay, Seymur Gahramanov, Leslie L. Muldoon, James A. Goodman, Ian J. Tagge, Audrey H. Selzer, Martin M. Pike, Edward A. Neuwelt, Charles S. Springer, Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: rat cerebral glioma blood volume determination. Journal of Magnetic Resonance. ,vol. 206, pp. 190- 199 ,(2010) , 10.1016/J.JMR.2010.07.004