Comparison of microvascular permeability measurements, K(trans), determined with conventional steady-state T1-weighted and first-pass T2*-weighted MR imaging methods in gliomas and meningiomas.

摘要: BACKGROUND AND PURPOSE: The widely accepted MR method for quantitating brain tumor microvascular permeability, Ktrans, is the steady-state T1-weighted gradient-echo (ssT1). Recently first-pass T2*-weighted (fpT2*) has been used to derive both relative cerebral blood volume (rCBV) and Ktrans. We hypothesized that Ktrans derived from ssT1 fpT2* methods will correlate differently in gliomas meningiomas because of unique differences morphologic functional status each vascular network. METHODS: Before surgery, 27 patients with newly diagnosed (WHO grade I–IV; n = 20) or (n 7) underwent conventional anatomic imaging 12 dynamic acquisitions followed by 60 images before after gadopentate dimeglumine administration. 3 hemodynamic variables—fpT2* rCBV, Ktrans—were calculated anatomically identical locations correlated glioma grade. values were compared meningiomas. RESULTS: All variables displayed distinct distributions among grades 2, 3, 4 using Kruskal-Wallis test. Only values, not could differentiate between lower-grade Wilcoxon rank sum was highly predictive gliomas, an estimated regression coefficient 0.49 (P CONCLUSION: Compared either more but