MRI-Tracked Tumor Vascular Changes in the Hours after Single-Fraction Irradiation
作者： Stephen L. Brown , Tavarekere N. Nagaraja , Madhava P. Aryal , Swayamprava Panda , Glauber Cabral
DOI: 10.1667/RR13458.1
关键词: Brain tumor 、 Nuclear medicine 、 Irradiation 、 Dose–response relationship 、 Magnetic resonance imaging 、 Glioma 、 Medicine 、 Human brain 、 Cerebral blood flow 、 Blood flow
摘要: The purpose of this study was to characterize changes in tumor vascular parameters hours after a single radiation exposure an orthotopic brain model. U-251 human tumors were established intracerebrally rat brains, and blood flow, forward volume transfer constant (Ktrans) interstitial fraction (ve) measured using magnetic resonance imaging (MRI). Tumors stereotactic treatment 20 Gy. Vascular assessed one additional time between 2 24 h irradiation. After the second MRI session, tissue histology examined for gross apoptosis. In separate studies, cerebral flow nonimplanted controls before Gy irradiation, implanted rats at 6 Significant observed tumor-bearing brains Two irradiat...
allenpress.com
rrjournal.org参考文章(38)
Joe M. McCord, Ranjan S. Roy, Stephen W. Schaffer, Free Radicals and Myocardial Ischemia Springer, Boston, MA. pp. 183- 189 ,(1985) , 10.1007/978-1-4757-1287-2_14
Schaffer Sw, McCord Jm, Roy Rs, Free radicals and myocardial ischemia. The role of xanthine oxidase. Advances in myocardiology. ,vol. 5, pp. 183- 189 ,(1985)
Madhava P. Aryal, Tavarekere N. Nagaraja, Stephen L. Brown, Mei Lu, Hassan Bagher-Ebadian, Guangliang Ding, Swayamprava Panda, Kelly Keenan, Glauber Cabral, Tom Mikkelsen, James R. Ewing, Intratumor distribution and test–retest comparisons of physiological parameters quantified by dynamic contrast‐enhanced MRI in rat U251 glioma NMR in Biomedicine. ,vol. 27, pp. 1230- 1238 ,(2014) , 10.1002/NBM.3178
David J. Chaplin, Michael R. L. Stratford, Charles S. Parkins, Sally A. Hill, Madeleine F. Dennis, Ischemia Reperfusion Injury in Tumors: The Role of Oxygen Radicals and Nitric Oxide Cancer Research. ,vol. 55, pp. 6026- 6029 ,(1995)
JasonK Rockhill, LiaM Halasz, Stereotactic radiosurgery and stereotactic radiotherapy for brain metastases. Surgical Neurology International. ,vol. 4, pp. 185- ,(2013) , 10.4103/2152-7806.111295
Madhava P. Aryal, Tavarekere N. Nagaraja, Kelly A. Keenan, Hassan Bagher-Ebadian, Swayamprava Panda, Stephen L. Brown, Glauber Cabral, Joseph D. Fenstermacher, James R. Ewing, Dynamic contrast enhanced MRI parameters and tumor cellularity in a rat model of cerebral glioma at 7 T. Magnetic Resonance in Medicine. ,vol. 71, pp. 2206- 2214 ,(2014) , 10.1002/MRM.24873
Wilson B Chwang, Rajan Jain, Hassan Bagher‐Ebadian, Siamak P Nejad‐Davarani, ASM Iskander, Ashley VanSlooten, Lonni Schultz, Ali S Arbab, James R Ewing, None, Measurement of rat brain tumor kinetics using an intravascular MR contrast agent and DCE-MRI nested model selection Journal of Magnetic Resonance Imaging. ,vol. 40, pp. 1223- 1229 ,(2014) , 10.1002/JMRI.24469
Gerald L. DeNardo, Mary J. Stasch, Robert F. Kallman, Blood Flow in Irradiated Mouse Sarcoma as Determined by the Clearance of Xenon-133 Cancer Research. ,vol. 32, pp. 483- 490 ,(1972)
James R. Ewing, Hassan Bagher-Ebadian, Model Selection in Measures of Vascular Parameters using Dynamic Contrast Enhanced MRI: Experimental and Clinical Applications NMR in Biomedicine. ,vol. 26, pp. 1028- 1041 ,(2013) , 10.1002/NBM.2996
Mitomu Kioi, Hannes Vogel, Geoffrey Schultz, Robert M. Hoffman, Griffith R. Harsh, J. Martin Brown, Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice Journal of Clinical Investigation. ,vol. 120, pp. 694- 705 ,(2010) , 10.1172/JCI40283