A Quantitative MRI Method for Imaging Blood-Brain Barrier Leakage in Experimental Traumatic Brain Injury

摘要: Blood-brain barrier (BBB) disruption is common following traumatic brain injury (TBI). Dynamic contrast enhanced (DCE) MRI can longitudinally measure the transport coefficient Ktrans which reflects BBB permeability. measurements however are not widely used in TBI research because it generally considered to be noisy and possesses low spatial resolution. We improved spatiotemporal resolution signal sensitivity of rats by using a high-sensitivity surface transceiver coil. To overcome drop off profile coil, pre-scan module was map flip angle (B1 field) magnetization (M0) distributions. A series T1-weighted gradient echo images were acquired fitted extended Kety model with reversible or irreversible leakage, best selected F-statistics. applied this method study rat one hour controlled cortical impact (mild moderate TBI), observed clear depiction damage around regions, matched that outlined Evans Blue extravasation. Unlike relatively uniform T2 showing cerebral edema, shows pronounced heterogeneous displaying nonlinear relationship T2. This also compatible use coil high-contrast two-coil arterial spin-labeling for blood flow measurement, enabling more comprehensive investigation pathophysiology TBI.