Determination of the MRI contrast agent concentration time course in vivo following bolus injection: Effect of equilibrium transcytolemmal water exchange
作者： Charles S Landis , Xin Li , Frank W Telang , Jeffrey A Coderre , Peggy L Micca
DOI: 10.1002/1522-2594(200010)44:4<563::AID-MRM10>3.0.CO;2-#
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摘要: For bolus-tracking studies, it is commonly assumed that CR concentration bears a linear relationship with the measured (usually longitudinal) 1H2O relaxation rate constant, R*1 ≡(T1 *)–1. This requires equilibrium transcytolemmal water exchange be in fast limit (FXL). However, though systems remain exchange, FXL will not usually obtain. Here, consequences are considered: 1) measurement of R1 * itself can affected, 2) resultant non-linear [CR]-dependence causes significant error by assuming FXL, 3) thermodynamic [CR] (based on space which actually distributed) determined, 4) permeability may estimated, and 5) pharmacokinetic parameters factored. 30-sec, 0.17 mmol/kg dose GdDTPA2–, assumption underestimates maximum rat thigh muscle factor almost two. Similar results obtained for brain GS-9L gliosarcoma tumor model. Magn Reson Med 44:563–574, 2000. Published 2000 Wiley-Liss, Inc.
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