Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population
作者： Li-Xin Qiu , Jing He , Lei Cheng , Fei Zhou , Meng-Yun Wang
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摘要: // Li-Xin Qiu 1, 2, * , Jing He 3, Lei Cheng Fei Zhou 2 Meng-Yun Wang Meng-Hong Sun 4 Xiao-Yan Jin Li 1 Wei-Jian Guo Ya-Nong 5 Ya-Jun Yang 6, 7 Jiu-Cun Xiao-Dong Zhu Qing-Yi Wei 8 Department of Medical Oncology, Fudan University Shanghai Cancer Center, College, University, Shanghai, China Institute, Collaborative Innovation Center for Medicine, 3 Pediatric Surgery, Guangzhou Women and Children’s Guangzhou, Pathology, Gastric Soft Tissue Sarcoma 6 Ministry Education Key Laboratory Contemporary Anthropology State Genetic Engineering, School Life Sciences, Fudan-Taizhou Institute Health Jiangsu, Duke Durham, NC, USA These authors have contributed equally to this work Correspondence to: Zhu, e-mail: xddr@netease.com Wei, weiqingyi@yahoo.com Qingyi.wei@duke.edu Keywords: PRKA71, polymorphism, gastric cancer, genetic susceptibility Received: August 04, 2015 Accepted: October 09, Published: 15, 2015 ABSTRACT Published data on the association between PRKAA1 rs13361707 T > C polymorphism cancer (GCa) were inconclusive. To derive a more precise estimation association, we conducted large-scale GCa study 1,124 cases 1,194 controls confirm in an eastern Chinese population. Our results showed that allele increased GC risk population [CT vs. TT, odds ratio (OR) = 1.72, 95% confidence interval (CI) 1.40–2.12; CC OR 2.15, 95%CI 1.70–2.71; CT/CC 1.86, 1.53–2.26; vs.TT/CT, 1.49, 1.24–1.79]. In addition, with was still significant subgroups, when stratified by age, sex, tumor site, drinking smoking status. Moreover, findings present validated our further meta-analysis. summary, these indicated low-penetrate factor GCa.
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