Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids

摘要: Background Although inhaled corticosteroids (ICSs) are effective in preventing deterioration asthma control, at least half of subjects with mild-to-moderate will remain stable when these agents discontinued. Objective We sought to determine whether noninvasive markers inflammation predict which individuals maintain control after discontinuation ICSs. Methods analyzed data obtained from 164 who participated a 16-week trial comparing the effects continued ICS use switch salmeterol or placebo. Results In comparison use, placebo was associated increased rates over 16 weeks (9.3% vs 24.1% and 37.5%, respectively; P =.04 20 , measured randomization 2 randomization, were significant predictors subsequent discontinued However, both induced sputum eosinophil counts changes before cessation ICSs predicted (area under receiver-operating characteristic curve, 0.771 [ Conclusion On basis model treatment strategy, we estimate that allocating therapy on could allow 48% discontinue without an risk period 14 weeks.