Different effects of angiotensin receptor blockade on end-organ damage in salt-dependent and salt-independent hypertension.

摘要: Background— Although angiotensin II type 1 receptor blockers have emerged as effective antihypertensive agents, it is not known how efficacious these agents are in treating hypertension-associated target organ damage. Methods and Results— The present study was undertaken to compare the effect of inhibition on progression damage observed 2 models hypertension, namely, salt-sensitive nitric oxide synthase inhibition–mediated hypertension. Effective (16.4 μmol/kg) ineffective (0.8 4.9 doses candesartan cilexetil were initiated after hypertension established. Both low- high-dose significantly reduced cardiac renal inhibitor model (P<0.05 versus untreated); however, caused a significant increase Dahl untreated). Interestingly, beneficial...