Myron Gordon Award paper: Microbes, T-cell diversity and pigmentation.

摘要: Melanocytes are static, minimally proliferative cells. This leaves them vulnerable in vitiligo. Yet upon malignant transformation, they form vicious tumors. profound switch physiology is accompanied by genetic change and driven environmental factors. If UV exposure younger years supports transformation melanoma formation, it can likewise impart mutations on melanocytes that reduce their viability, to initiate A wide variety of microbes influence these diametrically opposed outcomes before either disease takes hold. These vehicles we only beginning study. Once a modification occurs, there immune cells ready respond. Though does not act alone, the T cell among most decisive responders this process. The same biochemical process offered skin protection producing melanin become an Achilles heel for when target melanosomal enzymes or, occasion, neoantigens. precise, determined, consequential strike. Here, probe relationship between microbiome its metabolites, epithelial integrity, activation benign vitiligo melanoma.