Spindle Cell Amelanotic Lesion of the Tongue: a Diagnostic and Therapeutic Challenge

作者: Vinay Kumar , Mridula Shukla , Umakanth Goud , Devendra Kumar Ravi , Mohan Kumar

DOI: 10.1007/S12262-012-0575-8

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摘要: Melanomas occurring in the tongue are rarer, and when nonpigmented they often misdiagnosed as squamous cell carcinoma. We report a 50-year-old woman who presented with 3 × 2 cm soft swelling of mucosal color on right lateral border tongue. The patient had multiple recurrences was treated by radical radiotherapy, operated thrice received adjuvant 5 MIU interferon weekly. During last surgery, she developed cerebral infarcts died fifth postoperative day. Oral amelanotic melanoma is very aggressive potential lethal tumor that presents diagnostic dilemma.

参考文章(23)
Shailesh M Gondivkar, Shirish Degwekar, Rahul Bhowate, Atul Indurkar, Primary oral malignant melanoma--a case report and review of the literature. Quintessence International. ,vol. 40, pp. 41- 46 ,(2009) , 10.3290/J.QI.A14113
Christian Gwosdz, Kathrin Scheckenbach, Oliver Lieven, Julia Reifenberger, Andreas Knopf, Henning Bier, Vera Balz, Comprehensive analysis of the p53 status in mucosal and cutaneous melanomas International Journal of Cancer. ,vol. 118, pp. 577- 582 ,(2006) , 10.1002/IJC.21366
Jonathan M. Owens, Dianna B. Roberts, Jeffrey N. Myers, The Role of Postoperative Adjuvant Radiation Therapy in the Treatment of Mucosal Melanomas of the Head and Neck Region Archives of Otolaryngology–Head & Neck Surgery. ,vol. 129, pp. 864- 868 ,(2003) , 10.1001/ARCHOTOL.129.8.864
Manju L. Prasad, Snehal G. Patel, Andrew G. Huvos, Jatin P. Shah, Klaus J. Busam, Primary mucosal melanoma of the head and neck: a proposal for microstaging localized, Stage I (lymph node-negative) tumors. Cancer. ,vol. 100, pp. 1657- 1664 ,(2004) , 10.1002/CNCR.20201
I Satzger, T Schaefer, U Kuettler, V Broecker, B Voelker, H Ostertag, A Kapp, R Gutzmer, Analysis of c-KIT expression and KIT gene mutation in human mucosal melanomas. British Journal of Cancer. ,vol. 99, pp. 2065- 2069 ,(2008) , 10.1038/SJ.BJC.6604791
Juliano P. Nakashima, Célia M. Viégas, Ana L. Fassizoli, Marcelo Rodrigues, Leonardo A.G. Chamon, João H.C. Silva, Fernando L. Dias, Carlos M. Araújo, Postoperative Adjuvant Radiation Therapy in the Treatment of Primary Head and Neck Mucosal Melanomas Operations Research Letters. ,vol. 70, pp. 344- 351 ,(2008) , 10.1159/000163029
Manju L. Prasad, Snehal Patel, Stacy Hoshaw-Woodard, Margarita Escrig, Jatin P. Shah, Andrew G. Huvos, Klaus J. Busam, Prognostic factors for malignant melanoma of the squamous mucosa of the head and neck. The American Journal of Surgical Pathology. ,vol. 26, pp. 883- 892 ,(2002) , 10.1097/00000478-200207000-00006
J. Gregory McKinnon, William A. Kokal, James P. Neifeld, Saul Kay, Natural history and treatment of mucosal melanoma. Journal of Surgical Oncology. ,vol. 41, pp. 222- 225 ,(1989) , 10.1002/JSO.2930410406
Patrick J. Bradley, David Hoskin, Hyercalcaemia in head and neck squamous cell carcinoma Current Opinion in Otolaryngology & Head and Neck Surgery. ,vol. 14, pp. 51- 54 ,(2006) , 10.1097/01.MOO.0000193176.54450.C4