Startle amplitude and fear in an acoustic startle paradigm: lesions to the brachium of the inferior colliculus or the lateral tegmental tract.
作者： Robert N. Leaton , Frederic H. Brucato
DOI: 10.1037//0735-7044.115.2.477
关键词:
摘要: In 2 experiments, startle amplitude and stimulus-induced freezing (an index of fear) were measured in an acoustic response (ASR) paradigm rats. Lesions to lateral tegmental tract (LTG), a pathway medial brachium the inferior colliculus (BIC), significantly decreased produced persistent 5-fold increase ASR compared with sham-operated controls. BIC increased both (2-fold) freezing. Neither nor LTG lesions affected when was elicited by brief footshock stimulus. Characteristics lesion effects tested manipulations interstimulus interval, stimulus intensity, prepulse inhibition. The data suggest (a) ascending that carries fear-inducing dimensions (b) descending provides tonic inhibition sensory input circuitry.
sci-hub.st 参考文章(57)
Donald S. Leitner, Alice S. Powers, Howard S. Hoffman, The neural substrate of the startle response Physiology & Behavior. ,vol. 25, pp. 291- 297 ,(1980) , 10.1016/0031-9384(80)90219-X
Jeffrey B. Rosen, Janice M. Hitchcock, Catherine B. Sananes, Mindy J. D. Miserendino, Michael Davis, A direct projection from the central nucleus of the amygdala to the acoustic startle pathway: anterograde and retrograde tracing studies. Behavioral Neuroscience. ,vol. 105, pp. 817- 825 ,(1991) , 10.1037/0735-7044.105.6.817
Michael Davis, Janice M. Hitchcock, Efferent pathway of the amygdala involved in conditioned fear as measured with the fear-potentiated startle paradigm. Behavioral Neuroscience. ,vol. 105, pp. 826- 842 ,(1991) , 10.1037//0735-7044.105.6.826
Marc D. Tischler, Michael Davis, A visual pathway that mediates fear-conditioned enhancement of acoustic startle Brain Research. ,vol. 276, pp. 55- 71 ,(1983) , 10.1016/0006-8993(83)90548-6
Michael Davis, Phillip M. Gendelman, Plasticity of the acoustic startle response in the acutely decerebrate rat. Journal of Comparative and Physiological Psychology. ,vol. 91, pp. 549- 563 ,(1977) , 10.1037/H0077345
Howard S. Hoffman, James R. Ison, Reflex modification in the domain of startle: I. Some empirical findings and their implications for how the nervous system processes sensory input. Psychological Review. ,vol. 87, pp. 175- 189 ,(1980) , 10.1037/0033-295X.87.2.175
Jiro Iwata, Joseph E. LeDoux, Mary P. Meeley, Stephen Arneric, Donald J. Reis, Intrinsic neurons in the amygdaloid field projected to by the medial geniculate body mediate emotional responses conditioned to acoustic stimuli Brain Research. ,vol. 383, pp. 195- 214 ,(1986) , 10.1016/0006-8993(86)90020-X
David L. Walker, Michael Davis, Involvement of the dorsal periaqueductal gray in the loss of fear-potentiated startle accompanying high footshock training. Behavioral Neuroscience. ,vol. 111, pp. 692- 702 ,(1997) , 10.1037//0735-7044.111.4.692
Philip M. Groves, Richard F. Thompson, Habituation: A dual-process theory. Psychological Review. ,vol. 77, pp. 419- 450 ,(1970) , 10.1037/H0029810
Sebastian P. Grossman, Lore Grossman, Linda Walsh, Functional organization of the rat amygdala with respect to avoidance behavior. Journal of Comparative and Physiological Psychology. ,vol. 88, pp. 829- 850 ,(1975) , 10.1037/H0076396