Timing of the Acoustic Startle Response in Mice: Habituation and Dishabituation as a Function of the Interstimulus Interval

摘要: The hypothesis that the standard acoustic startle response (ASR) paradigm contains elements of interval timing was tested. Acoustic stimuli were presented at a 10-s interstimulus (ISI) for 100 trials leading to habituation ASR. ISI then changed either shorter (5-s) or longer (15-s) duration using betweensubjects design. Dishabituation ASR used measure degree temporal generalization interval-timing process. showed dishabituation both and values on first trial following change in ISI. resulting from temporary rapidly returned levels showing rate sensitivity frequency stimulus presentation. Interval may be feature this paradigm, it serves anticipate time occurrence subsequent prepare response, provides computational dimension lacking process per se.