Noninvasive parameters of bone metabolism.

摘要: Markers of bone formation determined in serum include alkaline phosphatase, bone-specific osteocalcin [bone gamma-carboxyglutamic acid peptide (BGP) and procollagen type I carboxyterminal propeptide. Recently, advances have been made the immunoassay phosphatase. This is a marker for osteoblastic activity; it very stable not primarily dependent on kidney function because degraded liver. BGP specific increases during bed rest (which involves increased resorption), stable. Furthermore, elimination glomerular filtration rate. Procollagen propeptide as sensitive phosphatase less women after menopause. Urinary pyridinoline deoxypyridinoline by high-performance liquid chromatography are regarded best methods measuring resorption. These might be replaced collagen crosslinked N-telopeptide or CrossLaps future laboratories equipped with system. Serum markers resorption currently under investigation. An tartrate-resistant should promising tool quantification