Dupuytren's disease in type I diabetic subjects: investigation of biochemical markers of type III and I collagen.
作者： P. E. T. Arkkila , E. Seppänen , J. S. Viikari , T. Rönnemaa , P. J. Koskinen
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摘要: OBJECTIVE To clarify whether biochemical markers of collagen type III and I metabolism show alterations in diabetic subjects with Dupuytren's disease (DD) compared to those without DD. METHODS DD was assessed a total 28 subjects, mean age 43.4 +/- 9.5 (SD) duration diabetes 25.2 9.7 years. Concentrations aminoterminal propeptide procollagen (PIIINP), carboxyterminal (PICP) cross-linked telopeptide (ICTP) serum excretion N-telopeptides (NTX) deoxypyridinoline crosslinks (DPyr) into urine were measured. RESULTS The prevalence 32% (9 subjects). Average ICTP 2.7 0.8 micrograms/l 3.6 1.2 (p = 0.0276). No significant association between other found. reference intervals PIIINP exceeded only 1 2 respectively, they both had CONCLUSION degradation might be increased overall implication that synthesis or did not differ enough from reflect changes the collagen.
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