Study on the action of D-norgestrel as a postcoital contraceptive agent
作者： J. Spona , K. Matt , W.H.F. Schneider
DOI: 10.1016/0010-7824(75)90048-7
关键词:
摘要: Abstract This study was undertaken to investigate possible mechanisms of action D-norgestrel as a contraceptive agent after the results large clinical trials on postcoital contraception with were known. Previously, in total 4,631 patients 41,802 months use, general failure rate 3.5 and corrected 1.7 observed. In this communication, 400 mcg investigated when taken orally by six subjects day 12, days 10 8, 10, 12 cycle, 2nd 4th day, 2nd, 6th LH-peak. Karyopyknotic index, cervical function, Spinnbarkeit crystallization mucus, serum levels 17β-estradiol, progesterone LH studied daily from 8th cycle. Preovulatory application resulted inhibition peripheral parameters menstrual Furthermore, midcycle elevation found inhibited reduced treated follicular phase. Neither preovulatory nor postovulatory progestagen appeared interfere luteal phase It is concluded that one main actions has be sought function
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sci-hub.se 参考文章(17)
J. Spona, Rasche radioimmunologische Bestimmung des luteinisierenden Hormons (LH) in Serum Fresenius Journal of Analytical Chemistry. ,vol. 261, pp. 386- 387 ,(1972) , 10.1007/BF00786999
John McLean Morris, Gertrude van Wagenen, Interception: The use of postovulatory estrogens to prevent implantation American Journal of Obstetrics and Gynecology. ,vol. 115, pp. 101- 106 ,(1973) , 10.1016/0002-9378(73)90095-1
K. THOMAS, R. WALCKIERS, J. FERIN, Biphasic pattern of LH midcycle discharge. The Journal of Clinical Endocrinology and Metabolism. ,vol. 30, pp. 269- 272 ,(1970) , 10.1210/JCEM-30-2-269
Esteban Kesserü, Alfredo Larrañaga, Julio Parada, Postcoital contraception with D-norgestrel Contraception. ,vol. 7, pp. 367- 379 ,(1973) , 10.1016/0010-7824(73)90139-X
Rodney P. Shearman, Post-coital contraception a review Contraception. ,vol. 7, pp. 459- 476 ,(1973) , 10.1016/0010-7824(73)90018-8
F. Garmendia, E. Kesserü, L. Llerena, Serum LH concentration in women under contraceptive treatment with estrogen-free progestagens. Hormone and Metabolic Research. ,vol. 5, pp. 134- 138 ,(1973) , 10.1055/S-0028-1093979
G. E. Abraham, K. Hopper, D. Tulchinsky, R. S. Swerdloff, W. D. Odell, Simultaneous Measurement of Plasma Progesterone, 17-Hydroxyprogesterone and Estradiol-17B by Radioimmunoassay Analytical Letters. ,vol. 4, pp. 325- 335 ,(1971) , 10.1080/00032717108058620
ANDREW V. SCHALLY, TOMMIE W. REDDING, AKIRA ARIMURA, Effect of sex steroids on pituitary responses to LH-and FSH-releasing hormone in vitro. Endocrinology. ,vol. 93, pp. 893- 902 ,(1973) , 10.1210/ENDO-93-4-893
GUY E. ABRAHAM, RONALD SWERDLOFF, DAN TULCHINSKY, WILLIAM D. ODELL, Radioimmunoassay of Plasma Progesterone The Journal of Clinical Endocrinology and Metabolism. ,vol. 32, pp. 619- 624 ,(1971) , 10.1210/JCEM-32-5-619
E. Diczfalusy, U. Goebelsmann, E. Johannisson, K.-G. Tillinger, L. Wide, PITUITARY AND OVARIAN FUNCTION IN WOMEN ON CONTINUOUS LOW DOSE PROGESTOGENS; EFFECT OF CHLORMADINONE ACETATE AND NORETHISTERONE European Journal of Endocrinology. ,vol. 62, pp. 679- 693 ,(1969) , 10.1530/ACTA.0.0620679