Use of ranitidine in children undergoing cardiopulmonary bypass.

摘要: Sixty children aged 6 wk to 10 yr were studied. The undergoing cardiopulmonary bypass (CPB) for correction of congenital heart defects. aim the study was provide prophylaxis stress-induced gastric ulceration by elevating pH at least 3.5. Two infusion regimes ranitidine compared: 0.1 and 0.2 mg/kg.h. period from induction anesthesia until end first 24 h after surgery. Both effective. 0.2-mg/kg.h produced a significantly higher plasma concentration throughout without any additional clinical benefit. produced, within 3 cessation CPB, significant elevation in mean 5.3. This paper concludes that 0.1-mg/kg.h is safe efficacious regime critically ill pediatric patient.