Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults.

摘要: Aims  To assess the prevalence of non-alcoholic fatty liver disease (NAFLD) and its association with impaired glucose metabolism in Japanese subjects. Methods  One thousand, nine hundred fifty subjects enrolled a general health examination programme from September 2002 to February 2003 were recruited. NAFLD was diagnosed if person showed ‘fatty liver’ on ultrasonography, his/her alcohol consumption, estimated by questionnaire, < 40 gram/week. A linear model used for comparison means metabolic variables adjusted age body mass index (BMI) between those without liver. Multivariate regression fasting plasma (FPG) as dependent variable performed 1547 non-diabetic individuals after adjusting age, gender, BMI NAFLD. Results  found 566 1950 health-check examinees (29%). Its increased increasing FPG levels: 27% subgroup normal glucose, 43% 62% newly diabetes. Adjusted FPG, HbA1c, triglyceride, total protein, albumin, AST ALT all significantly higher, while HDL cholesterol AST/ALT ratio lower than analysis that independently associated individuals. Conclusions  The 29% apparently healthy middle-aged adults metabolism.