Stimulation of the cervical sympathetic nerves increases intraocular pressure.

摘要: PURPOSE To test the hypothesis that a moderate electrical stimulation of cervical sympathetic nerves in rabbits can increase intraocular pressure (IOP). METHODS Electrical stimulations were performed anesthetized and conscious rabbits. Intraocular pressure, pupil size, concentrations aqueous humor components monitored. RESULTS In urethane-anesthetized rabbits, 5 V 1 ms at 2.5 Hz for hr then 20 2 caused short inhibition IOP decrease prolonged mydriasis. Concentrations norepinephrine (NE), neuropeptide Y (NPY), cyclic AMP (cAMP) elevated. Aqueous protein concentration was not changed. with ketamine, chlorpromazine, pentobarbital, same parameters increases size. NE cAMP increased, while NPY did change. When set 3 under this anesthesia, mydriasis persisted. However, only increased. either or delivered from portable stimulator 4 hr, starting before onset dark. Stimulations an light phase. The circadian elevation dark phase used, transient fall observed, eliminated. doubled receiving hr. CONCLUSIONS A