HIF-1's relationship to oxygen: simple yet sophisticated.

摘要: HIF-1 is a transcription factor which acts as master regulator co-ordinating oxygen homeostasis. An sensitive signal controlling provided by enzymatic hydroxylation reactions require molecular and modify specific prolyl asparaginyl residues in the HIF subunit. These act switches – enabling capture ubiquitin ligase, preventing transactivator recruitment. important challenge to understand how this simple principle used tailor response system diverse settings that occur complex organisms such ourselves. The emerging picture of many parameters are likely contribute, including cofactor availability regulated expression hydroxylase enzymes.