Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait

摘要: Survival to extreme ages clusters within families. However, identifying genetic loci conferring longevity and low morbidity in such longevous families is challenging. There debate concerning the survival percentile that best isolates component longevity. Here, we use three-generational mortality data from two large datasets, UPDB (US) LINKS (Netherlands). We study 20,360 unselected containing index persons, their parents, siblings, spouses, children, comprising 314,819 individuals. Our analyses provide strong evidence transmitted as a quantitative trait among survivors up top 10% of birth cohort. subsequently show advantage, mounting 31%, for individuals with surviving first second-degree relatives both databases across generations, even presence non-longevous parents. To guide future studies, suggest base case selection on cohort equally long-lived family members.