The role of ventral and dorsal striatum mGluR5 in relapse to cocaine-seeking and extinction learning.

摘要: Cocaine addiction is a chronic, relapsing disease characterized by an inability to regulate drug-seeking behavior. Here we investigated the role of mGluR5 in ventral and dorsal striatum regulating cocaine-seeking following both abstinence extinction. Animals underwent 2 weeks cocaine self-administration followed 3 home-cage abstinence. were then reintroduced operant chamber for context-induced relapse test, 7-10 days extinction training. Once responding was extinguished, cue-primed reinstatement test conducted. Both tests conducted presence either negative allosteric modulator, MTEP or vehicle infused into nucleus accumbens (NA) core dorsolateral (dSTR). We found that NA attenuated Blocking dSTR had no effect on context- cue-induced cocaine-seeking. However, intra-dSTR infusion day learning 4 after infusion. Furthermore, surface expression reduced LTD absent slices animals undergoing from but not sucrose self-administration. restored bath application VU-29, positive modulator mGluR5. Bath prevented induction animals. Taken together, this data indicates plays essential relapse, while modulates