Behavioral and pharmacological assessment of butyrylcholinesterase in rats.
作者： Raymond F. Genovese , Bhupendra P. Doctor
DOI: 10.1016/0091-3057(95)91937-L
关键词:
摘要: Advances in the treatment of organophosphorus (OP) toxicity have focussed on use exogenous cholinesterases to act as scavengers for OP agent. To further investigate feasibility scavenger approach, we evaluated effects highly purified horse serum butyrylcholinesterase (HS-BChE) performance rats. HS-BChE (5000 U, IP) produced substantial increases blood enzyme activity up 72 h after injection. had no effect acquisition or retention a passive avoidance task. In contrast, atropine sulfate (10 mg/kg) impaired when tested 168 administration. When examined 10 days following administration, (7500 either total daily motor circadian pattern activity. IM) also acute prolonged rate lever pressing maintained by VI56 s schedule food reinforcement. was observed confer significant, but partial, protection against response decreases OP, MEPQ, under These results suggest that, rats, HS-BChE, at doses that attenuate toxicity, may be devoid cognitive effects.
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