Relationship of the behavioral effects of aprophen, atropine and scopolamine to antagonism of the behavioral effects of physostigmine.
作者： Raymond F. Genovese , Timothy F. Elsmore , Jeffrey M. Witkin
DOI: 10.1016/0091-3057(90)90051-I
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摘要: Abstract Behavioral effects of aprophen, atropine and scopolamine, in rats, were examined under a multiple schedule food presentation at different injection-test times. The the varied treatments compared to ability drugs, identical conditions, prevent behavioral anticholineserase, physostigmine. Potencies antagonists decrease response rates across three log units. All produced dose-related attenuation suppressant In general, aprophen was better antagonist than scopolamine or atropine. It blocked physostigmine wider range doses other compounds, did so with less disruption. Although substantial differences between observed, all (when administered alone) positively correlated their efficacy as
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sci-hub.se 参考文章(15)
S Luz-Chapman, J M Herz, R Bruckstein, G Amitai, The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor. Molecular Pharmacology. ,vol. 32, pp. 678- 685 ,(1987)
J. H. Brown, Atropine, scopolamine and related antimuscarinic drugs The Pharmalogical Basis of Therapeutics. ,(1990)
Wayne Hoss, John Ellis, Muscarinic Receptor Subtypes in the Central Nervous System International Review of Neurobiology. ,vol. 26, pp. 151- 199 ,(1985) , 10.1016/S0074-7742(08)60074-4
J M Witkin, R K Gordon, P K Chiang, Comparison of in vitro actions with behavioral effects of antimuscarinic agents. Journal of Pharmacology and Experimental Therapeutics. ,vol. 242, pp. 796- 803 ,(1987)
R. M. EGLEN, R. L. WHITING, MUSCARINIC RECEPTOR SUBTYPES: A CRITIQUE OF THE CURRENT CLASSIFICATION AND A PROPOSAL FOR A WORKING NOMENCLATURE Journal of Autonomic Pharmacology. ,vol. 6, pp. 323- 346 ,(1986) , 10.1111/J.1474-8673.1986.TB00661.X
Jeffrey M. Witkin, Central and peripheral muscarinic actions of physostigmine and oxotremorine on avoidance responding of squirrel monkeys. Psychopharmacology. ,vol. 97, pp. 376- 382 ,(1989) , 10.1007/BF00439454
Raymond F. Genovese, Timothy F. Elsmore, Jeffrey M. Witkin, Environmental influences on the development of tolerance to the effects of physostigmine on schedule-controlled behavior. Psychopharmacology. ,vol. 96, pp. 462- 467 ,(1988) , 10.1007/BF02180025
Raymond F. Genovese, Timothy F. Elsmore, Lisa R. King, Tolerance to oxotremorine's effects on schedule-controlled behavior in physostigmine-tolerant rats Life Sciences. ,vol. 43, pp. 571- 576 ,(1988) , 10.1016/0024-3205(88)90060-4
J.M. Witkin, R. Alvarado-Garcia, L.A. Perez, K.M. Witkin, Central oxotremorine antagonist properties of pirenzepine Life Sciences. ,vol. 42, pp. 2467- 2473 ,(1988) , 10.1016/0024-3205(88)90345-1
Raymond F. Genovese, Effects of azaprophen, scopolamine and trihexyphenidyl on schedule-controlled behavior, before and after chronic physostigmine. European Journal of Pharmacology. ,vol. 176, pp. 271- 279 ,(1990) , 10.1016/0014-2999(90)90020-7