Renal transplantation in recipients over the age of 60: the impact of donor age.

作者: Halil Basar , Atilla Soran , Ron Shapiro , Carlos Vivas , Velma P. Scantlebury

DOI: 10.1097/00007890-199904270-00019

关键词:

摘要: BACKGROUND: Kidneys from older donors exhibit a series of changes characterized by glomerular, vascular, and tubular senescence. These may be aggravated atherosclerosis, hypertension, or diabetes, which are highly prevalent in individuals. METHODS: We analyzed the outcome after transplantation 230 recipients over age 60, who received transplants between February 1990 December 1996. assessed 1- 5-year patient graft survival, quality renal function, tacrolimus levels, incidence rejection, delayed compared outcomes kidneys 60 (group 1, n = 40) with those under 2, 190). There were no differences two groups terms recipient sex, race, age, cold ischemia time. Immunosuppression was steroids 61% cases; remainder patients, third agent, either azathioprine, cyclophosphamide (for 1 week), mycophenolate mofetil administered as well. The median follow-up 31.5 months (range: 1-86). RESULTS: In receiving tacrolimus-based immunosuppression, overall survival at 5 years 90% 76%, not significantly compromised kidney donor 60. 1-and actuarial 84% 64%; it 73% 52%, whereas 87% 66% (P<0.05). Most effect on seen year. mean serum creatinine 2.6+/-2.7 mg/dl, without any difference groups. Although function higher this did reach statistical significance. CONCLUSIONS: remain reasonable, inferior call into question proposals to utilize preferentially recipients.

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