p53-independent activities of MDM2 and their relevance to cancer therapy.

摘要: The feed-back auto-regulatory loop between p53 and MDM2 has been extensively investigated. is under the transcriptional control of p53, acts as a negative regulator p53. There increasing evidence, however, supporting notion that activities independent In absence may retain its role in cell cycle control, differentiation, fate determination, DNA repair, transcription regulation, signal transduction steroid receptors, cellular response to hypoxia, internalization surface other processes. also oncogenic transformational Moreover, anti-MDM2 antisense oligonucleotides have vitro vivo antitumor activity chemosensitizing radiosensitizing effects several human cancer models, regardless their status. this article, interactions with various proteins are considered. studies reviewed provide basis for developing novel inhibitors therapy against malignancies.